Stapokibart

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant humanized monoclonal antibody directed against the alpha chain of the interleukin-4 receptor (IL-4RA; IL-4R alpha), with potential anti-inflammatory and immunomodulatory activities. Upon administration, stapokibart selectively binds to IL-4RA. This disrupts IL-4/IL-13 signaling and prevents the activation of downstream pathways that mediate type 2 inflammation. IL-4 and IL-13 receptors are present on the surface of numerous cells involved in the pathophysiology of type-2 helper T-cell (Th2) allergic responses, including B-lymphocytes, eosinophils, dendritic cells (DCs), monocytes, macrophages, basophils, keratinocytes, bronchial epithelial cells, endothelial cells, fibroblasts, and airway smooth muscle cells.

**Synonyms:** - Anti-IL-4 Receptor Alpha Monoclonal Antibody CM310 - Anti-IL-4RA Monoclonal Antibody CM310 - Anti-interleukin-4 Receptor Subunit Alpha Monoclonal Antibody CM310 - CM 310 - CM-310 - CM310 - STAPOKIBART