Isocoumarin NM-3

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable antiangiogenic isocoumarin with potential antineoplastic activity. NM-3 inhibits vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby inhibiting endothelial cell proliferation. This agent also induces apoptosis by a mechanism involving reactive oxygen species. (NCI04)

**Synonyms:** - NM-3 - NM-3