TRPC6 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TRPC6 wild-type allele is located in the vicinity of 11q22.1 and is approximately 421 kb in length. This allele, which encodes short transient receptor potential channel 6 protein, plays a role in calcium transport mediated by a diacylglycerol (DAG)/phosphatidylinositol second messenger system. Several point mutations in the gene are associated with focal segmental glomerulosclerosis 2.

**Synonyms:** - FSGS2 - Focal Segmental Glomerulosclerosis 2 Gene - TRP6 - Transient Receptor Potential Cation Channel Subfamily C Member 6 wt Allele - Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Gene - Transient Receptor Potential, Drosophila, Homolog of, 6 Gene