LIPA wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LIPA wild-type allele is located in the vicinity of 10q23.31 and is approximately 201 kb in length. This allele, which encodes lysosomal acid lipase/cholesteryl ester hydrolase protein, plays a role in the lysosomal metabolism of low density lipoproteins. Loss of function gene mutations are associated with cholesteryl ester storage disease and Wolman disease.

**Synonyms:** - CESD - LAL - Lipase A, Lysosomal Acid Gene - Lipase A, Lysosomal Acid Type wt Allele - Lipase A, Lysosomal Acid, Cholesterol Esterase Gene - Wolman Disease Gene