Immune Effector Cell Associated Neurotoxicity Syndrome Grade 3

**Semantic type:** Disease or Syndrome

**Definition:** Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0, 1, or 2 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of greater than or equal to 9 (for children 12 and under), the ability of the affected individual to awaken only to tactile stimulus, clinical focal or generalized seizures that resolve rapidly, or non-convulsive seizures detected by electroencephalography (EEG) that resolve with intervention, and local cerebral edema evident on neuroimaging.

**Synonyms:** - ICANS Grade 3 - ICANS Grade 3