PSMA-targeting T-cell Redirecting Agent JNJ-80038114

**Semantic type:** Pharmacologic Substance

**Definition:** An agent that targets the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and redirects T-cells to PSMA-expressing tumor cells, with potential antineoplastic activity. Although the mechanism of action has not been elucidated, upon administration, PSMA-targeting T-cell redirecting agent JNJ-80038114 targets PSMA found on PSMA-expressing tumor cells, and redirects T-cells to the PSMA-expressing tumor cells. This may result in T-cell-mediated cell death of PSMA-expressing tumor cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.

**Synonyms:** - JNJ 80038114 - JNJ-80038114 - JNJ80038114 - PSMA-targeted T-cell Redirecting Agent JNJ-80038114