Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of tumor-infiltrating lymphocytes (TILs) that have been genetically engineered to express membrane-bound IL-15 (mbIL15), with potential immunostimulating and antineoplastic activities. Upon introduction of the mbIL15-expressing TILs OBX-115, the TILs target and kill tumor cells. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells. Sustained IL-15 signaling enhances TIL persistence and potency compared to un-engineered TILs. OBX-115 may replace the need for concomitant administration of systemic IL-2 which is needed to improve the efficacy of conventional TILs.

**Synonyms:** - CytoTIL15 - IL-15-engineered TILs OBX-115 - IL-15-engineered tumor-infiltrating lymphocytes OBX-115 - IL15-engineered TILs OBX-115 - OBX 115 - OBX-115 - OBX115 - bIL15-expressing TILs OBX-115