Activating MAP2K1 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the MAP2K1 gene that results in constitutive activation of both dual specificity mitogen-activated protein kinase kinase 1 and its downstream signaling pathways.

**Synonyms:** - Activating MAP2K1 Mutation - Activating MAPKK1 Gene Mutation - Activating MEK1 Gene Mutation - Activating MKK1 Gene Mutation - Activating Mitogen-Activated Protein Kinase Kinase 1 Gene Mutation - Activating PRKMK1 Gene Mutation - Gain of Function MAP2K1 Gene Mutation - Gain of Function MAP2K1 Mutation - MAP2K1 Activating Gene Mutation - MAP2K1 Activating Mutation - MAP2K1 Gain of Function Gene Mutation - MAP2K1 Gain of Function Mutation