Anti-HER3 Dendritic Cell Vaccine

**Semantic type:** Cell|Immunologic Factor|Pharmacologic Substance

**Definition:** A type-1-polarized dendritic cell (DC1)-based cancer vaccine against the tumor-associated antigen (TAA) human epidermal growth factor receptor 3 (HER3; ERBB3), with potential immunomodulatory and antineoplastic activities. Upon intratumoral administration of the anti-HER3 DC vaccine, the immune system gets exposed to HER3, which may stimulate a potent cytotoxic T-lymphocyte (CTL) response against HER3-positive tumor cells. This may result in tumor cell death and decreased tumor growth. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is overexpressed by a variety of cancers.

**Synonyms:** - Anti-HER-3 DC Vaccine - Anti-HER3 DC Vaccine - Anti-HER3 DC1 Vaccine - HER3-primed DC Vaccine - HER3-primed DC1 Vaccine - HER3-primed Dendritic Cell Vaccine