Peroxisome Proliferation

**Semantic type:** Phenomenon or Process

**Definition:** Associated with hepatocellular carcinomas, Peroxisome Proliferation occurs in epigenetic "non-genotoxic" responses of hepatocytes to diverse peroxisome proliferator chemicals and involves, probably by a steroid superfamily receptor-based mechanism (PPARs), altered expression of cellular growth and/or differentiation genes, induction of peroxisomal enzymes, and possibly oxidative stress.