Activating MAP2K2 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the MAP2K2 gene that results in constitutive activation of both dual specificity mitogen-activated protein kinase kinase 2 and its downstream signaling pathways.

**Synonyms:** - Activating MAP2K2 Mutation - Activating MAPKK2 Gene Mutation - Activating MEK2 Gene Mutation - Activating MKK2 Gene Mutation - Activating Mitogen-Activated Protein Kinase Kinase 2 Gene Mutation - Activating PRKMK2 Gene Mutation - Gain of Function MAP2K2 Gene Mutation - Gain of Function MAP2K2 Mutation - MAP2K2 Activating Gene Mutation - MAP2K2 Activating Mutation - MAP2K2 Gain of Function Gene Mutation - MAP2K2 Gain of Function Mutation