Copper Cu 67 Abefolastat Tesaroxetan

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of abefolastat tesaroxetan, two human prostate-specific membrane antigen (PSMA)-binding motifs linked to a sarcophagine (SAR)-based chelator and radiolabeled with the beta-emitting radioisotope copper Cu 67, with potential antineoplastic activity. Upon administration of copper Cu 67 abefolastat tesaroxetan, the PSMA-binding motifs target and bind to PSMA-expressing tumor cells, thereby delivering a cytotoxic dose of beta radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.

**Synonyms:** - 67Cu SAR-bisPSMA - 67Cu-SAR-bisPSMA - Copper Cu 67 SAR-bisPSMA - Copper Cu 67-SAR-bisPSMA - SAR-BIS-PSMA Cu 67