Elasomeran/Imelasomeran

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A bivalent booster vaccine consisting of elasomeran, a lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding the prefusion stabilized spike (S) protein of the SARS-CoV-2 Wuhan-Hu-1 strain (original), and imelasomeran, a LNP encapsulating mRNA encoding the prefusion stabilized S-protein of the SARS-CoV-2 Omicron variant B.1.1.529, with potential immunizing activity against SARS-CoV-2. Upon administration of elasomeran/imelasomeran, the LNP binds to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is then translated by ribosomes to produce the SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection.

**Synonyms:** - Original/Omicron BA.1 Bivalent COVID-19 Booster Vaccine mRNA-1273.214 - mRNA 1273.214 - mRNA-1273.214 - mRNA1273.214