Elasomeran/Davesomeran

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A bivalent booster vaccine consisting of elasomeran, a lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding the prefusion stabilized spike (S) protein of the SARS-CoV-2 Wuhan-Hu-1 strain (original), and davesomeran, a LNP encapsulating mRNA encoding the prefusion stabilized S-protein of the SARS-CoV-2 Omicron variant lineages BA.4 and BA.5 (Omicron BA.4/BA.5), with potential immunizing activity against SARS-CoV-2. Upon administration of elasomeran/davesomeran, the LNPs bind to the plasma membrane of cells and release the mRNA into the cells. The mRNA is then translated by ribosomes to produce the SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection.

**Synonyms:** - COVID-19 Bivalent Vaccine mRNA-1273.222 - Elasomeran/LNP-encapsulated mRNA-based Omicron BA.4/BA.5 Bivalent SARS-CoV-2 Vaccine mRNA-1273.222 - LNP-encapsulated mRNA-based Original and Omicron BA.4/BA.5 Bivalent SARS-CoV-2 Vaccine mRNA-1273.222 - Lipid Nanoparticle-encapsulated mRNA-based Original and Omicron BA.4/BA.5 Bivalent SARS-CoV-2 Vaccine mRNA-1273.222 - Moderna COVID-19 Vaccine, Bivalent, US - Original/Omicron BA.4/BA.5 Bivalent COVID-19 Booster Vaccine mRNA-1273.222 - mRNA 1273.222 - mRNA-1273.222 - mRNA1273.222