Anti-DLL3/CD3 Bispecific Antibody QLS31904

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific antibody directed against both the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/CD3 bispecific antibody QLS31904 binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.

**Synonyms:** - Anti-DLL3/Anti-CD3 Bispecific Antibody QLS31904 - DLL3 x CD3 Bispecific Antibody QLS31904 - QLS 31904 - QLS-31904 - QLS31904