SIRPA V2 Allele

**Semantic type:** Gene or Genome

**Definition:** Human SIRPA V2 allele is located within 20p13 and is approximately 45 kb in length. This allele, which encodes an isoform of tyrosine-protein phosphatase non-receptor type substrate 1 protein with 12 amino acid substitutions and 1 amino acid deletion in the immunoglobulin-like V-type domain, is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

**Synonyms:** - SIRPA Variant 2 Allele - SIRPalpha V2 Allele - SIRPalpha Variant 2 Allele - Signal Regulatory Protein Alpha V2 Allele - Signal Regulatory Protein-Alpha V2 Allele