Dolutegravir Sodium/Rilpivirine Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** A fixed two-agent combination of the sodium salt form of dolutegravir, a human immunodeficiency virus type 1 (HIV-1) integrase strand-transfer inhibitor (INSTI and the hydrochloride salt form of rilpivirine, a non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI), that may be used to treat HIV infection. Upon oral administration of dolutegravir sodium/rilpivirine hydrochloride, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. Rilpivirine binds to HIV RT, thereby blocking RNA and DNA-dependent DNA polymerase activities including viral replication, thereby further preventing HIV-1 replication.

**Synonyms:** - Dolutegravir/Rilpivirine - Dolutegravir/Rilpivirine - Juluca - Juluca - Rilpivirine/Dolutegravir