CD19-targeted CAR T Cells BZ019

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of T-lymphocytes that have been genetically modified and transduced with a non-viral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-targeted CAR T cells BZ019 recognize and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies.

**Synonyms:** - Anti-CD19 CAR T-cells BZ019 - Anti-CD19 CAR-T Cells BZ019 - BZ 019 - BZ-019 - BZ019