Cisplatin Micelle Formulation HA132

**Semantic type:** Pharmacologic Substance

**Definition:** A micelle formulation containing the inorganic platinum agent cisplatin, with potential antineoplastic activity. Upon administration, cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and growth inhibition of tumor cells.

**Synonyms:** - Cisplatin Micelle HA132 - HA 132 - HA-132 - HA132