Zifcasiran Sodium

**Semantic type:** Pharmacologic Substance

**Definition:** The sodium salt form of zifcasiran, an RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration, zifcasiran binds to and neutralizes mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key role in proliferation, progression and metastasis of tumors.

**Synonyms:** - ADS-007 Sodium - ARO HIF2 Sodium - ZIFCASIRAN SODIUM