C7R-expressing EBVSTs

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of human Epstein-Barr virus (EBV)-specific T-lymphocytes (EBVSTs) that have been genetically modified to express the constitutively active interleukin 7 (IL-7) receptor (C7R; IL-7R), with potential immunostimulating and antineoplastic activities. Upon administration, the CR7-expressing EBVSTs specifically recognize and bind EBV-infected tumor cells, resulting in tumor cell lysis. EBV, a ubiquitous human herpes virus, is associated with various malignancies, specifically nasopharyngeal carcinoma and lymphomas, including Hodgkin and non-Hodgkin. C7R triggers IL-7-mediated signaling that promotes T-cell proliferation and survival. The enhanced T-cell survival prolongs EBV-infected tumor cell killing and anti-tumor activity.

**Synonyms:** - C7R Modified EBV Specific T-Lymphocytes - C7R-EBV T-cells - C7R-expressing EBV-specific T-lymphocytes - C7R-expressing Epstein-Barr Virus-specific T-lymphocytes