Ulviprubart

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized, afucosylated monoclonal antibody directed against killer cell lectin-like receptor G1 (KLRG1), with potential immunomodulatory activity. Upon administration,ulviprubart targets and binds to KLRG1 expressed on highly differentiated effector CD8+ cytotoxic T-cells, and selectively depletes these highly differentiated cytotoxic T-cells while sparing other immune cells. This prevents the killing of cells by these highly differentiated cytotoxic T-cells in certain autoimmune diseases, such as the destruction of muscle tissue in inclusion body myositis, and the destruction of neutrophils and red blood cell precursors in T-cell large granular lymphocytic leukemia (T-LGLL).

**Synonyms:** - ABC 008 - ABC-008 - ABC008 - Anti-KLRG1 Monoclonal Antibody ABC-008 - Anti-KLRG1 Monoclonal Antibody ABC008 - ULVIPRUBART