T-Cell Receptor Activation

**Semantic type:** Molecular Function

**Definition:** Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include those between the T cell receptor and the major histocompatibility complex and those between CD28 and B7 family members. This process is involved in anergy and specification of the immune response to a particular antigen.

**Synonyms:** - T-Cell Receptor Interaction - TCR Activation - TCR Interaction