Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of donor-derived T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility antigen HA-1 (HA1), with potential immunomodulating and antineoplastic activities. Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01 positive patients, allogeneic anti-HA-1 TCR-engineered T-cells TSC-100 specifically recognize and bind to HA-1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing HA-1. HA-1 is a lineage-specific antigen found on leukemia cells.

**Synonyms:** - Allogeneic T-cell Receptor-engineered T-cells TSC-100 - HA-1-targeting TCR-T-cells TSC-100 - T-cell Receptor Engineered Donor T-Cells TSC-100 - TSC 100 - TSC-100 - TSC100