CARD11-BCL10-MALT1 Complex Inhibitor XL114

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of the caspase recruitment domain-containing protein 11 (CARD11; CARMA1)-B-cell lymphoma/leukemia 10 (BCL10)-mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) complex, with potential antineoplastic activity. Upon oral administration, CARD11-BCL10-MALT1 complex inhibitor XL114 inhibits the CARD11-BCL10-MALT1 complex and the CARD11-BCL10-MALT1 signaling pathway. This prevents the proliferation of susceptible cancer cells. The CARD11-BCL10-MALT1 signaling pathway promotes B- and T-cell lymphoma survival and proliferation.

**Synonyms:** - AUR 104 - AUR-104 - AUR104 - CARD11-BCL10-MALT1 Pathway Inhibitor XL114 - CARMA1-BCL10-MALT1 Pathway Inhibitor XL114 - XL 114 - XL-114 - XL114