pNGVL3-hICD Vaccine AST-301

**Semantic type:** Immunologic Factor|Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A plasmid DNA therapeutic cancer vaccine encoding the intracellular domain (ICD) of the HER-2/neu proto-oncogene, with potential immunomodulating and antineoplastic activities. Upon administration, the pNGVL3-hICD vaccine AST-301 expresses the HER-2/neu protein and elicits a HER-2-specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HER-2. The HER-2/neu ICD protein is highly immunogenic and, as a subdominant epitope, may be associated with decreased immune tolerance.

**Synonyms:** - AST 301 - AST-301 - AST301 - EP 301 - EP301 - HER-2/neu ICD Therapeutic Cancer Vaccine AST-301 - Plasmid DNA-based Vaccine Expressing HER2/neu ICD AST-301 - Therapeutic Cancer Vaccine AST-301 - pNGVL3-hICD Plasmid DNA-based Vaccine AST-301