Lirafugratinib Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of lirafugratinib, an orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.

**Synonyms:** - LIRAFUGRATINIB HYDROCHLORIDE - RLY 4008 Hydrochloride - RLY-4008 Hydrochloride - RLY4008 Hydrochloride