Famtozinameran

**Semantic type:** Pharmacologic Substance

**Definition:** A formulation consisting of lipid nanoparticle (LNP) encapsulating a nucleoside modified messenger RNA (modRNA) encoding an optimized form of the full-length viral spike (S) glycoprotein of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron variant lineages BA.4 and BA.5 (Omicron BA.4/BA.5), with potential immunizing and anti-COVID-19 activities. Upon administration of famtozinameran, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 S protein mRNA into the cells. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection.

**Synonyms:** - BNT162b2 Omicron BA.4/BA.5 - BNT162b2 Omicron BA.4/BA.5 mRNA - FAMTOZINAMERAN