Thyrointegrin AlphaVBeta3 Antagonist fb-PMT

**Semantic type:** Pharmacologic Substance

**Definition:** A fluorobenzyl polyethylene glycol (PEG) conjugated to tetraiodothyroacetic acid that targets the thyrointegrin alphaVbeta3, with potential antineoplastic activity. Upon administration, the thyrointegrin alphaVbeta3 antagonist fb-PMT targets and binds to alphaVbeta3 integrin. This results in the inhibition of angiogenesis and metastasis. The mechanism of actions (MOAs) through which fb-PMT exerts its actions may be more complex and may be through multiple signaling pathways. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is overexpressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.

**Synonyms:** - AlphaV/Beta3 Antagonist fb-PMT - Fluorobenzyl Polyethylene Glycol Conjugated Tetraiodothyroacetic Acid - NP 100 - NP 751 - NP-100 - NP-751 - NP100 - NP751 - fb-PMT