t(6;14)(p21;q32)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A cytogenetic abnormality that refers to the translocation of the short arm (p21) of chromosome 6 and the long arm (q32) of chromosome 14. This juxtaposes the CCND3 gene with the promoter regions of the immunoglobulin heavy chain gene locus, which results in overexpression of the G1/S-specific cyclin-D3 protein.

**Synonyms:** - t(6;14)(p21;q32) CCND3-IGH - t(6;14)(p21;q32) CCND3/IGH - t(6;14)(p21;q32) CCND3::IGH - t(6;14)(p21;q32) CCND3:IGH