t(14;20)(q32;q12)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A cytogenetic abnormality that refers to the translocation of the long arm (q32) of chromosome 14 and the long arm (q12) of chromosome 20. This juxtaposes the MAFB gene with the promoter regions of the immunoglobulin heavy chain gene locus, which results in overexpression of the transcription factor MafB protein.

**Synonyms:** - t(14;20)(q32;q12) IGH-MAFB - t(14;20)(q32;q12) IGH/MAFB - t(14;20)(q32;q12) IGH::MAFB - t(14;20)(q32;q12) IGH:MAFB