Fluorine F 18 Flotufolastat

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radiohybrid prostate specific membrane antigen (rhPSMA) ligand, rhPSMA-7.3, labeled with the radioisotope fluorine F 18, with potential imaging activity using positron emission tomography/computed tomography (PET/CT) or positron emission tomography/magnetic resonance imaging (PET/MRI). Upon administration of fluorine F 18 flotufolastat, the rhPSMA-7.3 moiety targets and binds to PSMA-expressing tumor cells. This allows for visualization of PSMA-expressing cells upon imaging. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.

**Synonyms:** - FLOTUFOLASTAT F-18 - RHPSMA-7.3C