Mesna

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)

**Synonyms:** - 2-Mercaptoethanesulfonate, Sodium Salt - 2-Mercaptoethanesulfonic Acid Sodium Salt - Ausobronc - D-7093 - Filesna - MESNA - Mercaptoethane Sulfonate - Mercaptoethanesulfonate - Mesnex - Mesnil - Mesnum - Mexan - Mistabron - Mistabronco - Mistabronco - Mitexan - Mucofluid - Mucofluid - Mucolene - Sodium 2-Mercaptoethane Sulfonate - Sodium 2-Mercaptoethanesulphonate - UCB 3983 - Uromitexan - Uromitexan - Ziken - mesna