4-Hydroxy-1-(3-Pyridyl)-1-Butanone

**Semantic type:** Organic Chemical

**Definition:** An analog of nicotinic acid with a hydroxy butyl ketone substituted for the carboxylic acid. 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB or 4-HPB) is formed upon hydrolysis of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN)-containing DNA and protein adducts. Detection of HPB in certain tissue or cellular samples can be indicative of exposure to tobacco-, tobacco-containing products and the tobacco-specific carcinogenic nitrosamines NNK and NNN.

**Synonyms:** - 1-Butanone, 4-hydroxy-1-(3-pyridinyl)- - 4-(3-pyridyl)-4-oxobutanol - 4-HPB - 4-HYDROXY-1-(3-PYRIDYL)-1-BUTANONE - 4-Hydroxy-1-(3-pyridinyl)-1-butanone - 4-Hydroxy-1-(pyridin-3-yl)butan-1-one - 4-Hydroxy-1-pyridin-3-ylbutan-1-one - 4-Oxo-4-(3-pyridyl)-1-butanol - HPB