Hypochlorous Acid-containing Wound Spray APR-TD011

**Semantic type:** Pharmacologic Substance

**Definition:** A sprayable topical formulation composed of a hypotonic acid-oxidizing solution containing the antimicrobial agent hypochlorous acid (HClO), with potential wound cleaning, wound healing and antimicrobial activity in certain skin conditions, such as epidermolysis bullosa (EB). Upon administration of the APR-TD011 spray to the affected area(s), HClO kills bacteria. The solution, having a low pH and high oxidation-reduction potential (ORP), changes the microbiome and creates a wound microenvironment that may be favorable to wound healing, may prevent skin infection, and may decrease inflammation by inhibiting the nuclear factor kappa B (NF-kB) pro-inflammatory pathway and by inactivating matrix metalloproteases (MMPs). This may also reduce itching and pain and increase cell growth, thereby further accelerating wound healing.

**Synonyms:** - APR TD011 - APR-TD011 - APRTD011 - Nexodyn AOS - Nexodyn AcidOxidizing Solution - Topical Solution APR-TD011