Anti-LAG-3/PD-1 Bispecific Antibody INCA32459

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A human immunoglobulin G1 (IgG1) Fc-silenced bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279; programmed death 1) and lymphocyte activation gene 3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-LAG-3/PD-1 bispecific antibody INCA32459 targets and binds to both PD-1 and LAG-3 expressed on T-cells and inhibits PD-1- and LAG-3-mediated downregulation of T-cell activation and proliferation. This may lead to cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 play key roles in suppressing T-cell activation and proliferation.

**Synonyms:** - Anti-LAG3/PD1 Bispecific Antibody INCA32459 - Anti-PD-1/Anti-LAG-3 Bispecific Antibody INCA32459 - Anti-PD-1/LAG-3 Bispecific Antibody INCA32459 - INCA 32459 - INCA-32459 - INCA32459 - PD-1 x LAG-3 Bispecific Antibody INCA32459