Activating RAF Family Alteration Positive

**Semantic type:** Laboratory or Test Result

**Definition:** An indication that mislocalization, aggregation, mutation, overexpression, fusion or rearrangement that results in constitutive RAF family serine/threonine-protein kinase activity and aberrant activation of downstream signaling pathways has been detected in a sample.

**Synonyms:** - Activating RAF Alteration - Activating RAF Alteration Positive - Activating RAF Family Kinase Alteration Positive - Activating RAF Kinase Alteration Positive - Activating Rapidly Accelerated Fibrosarcoma Alteration Positive - Activating Rapidly Accelerated Fibrosarcoma Family Kinase Alteration Positive - Activating Rapidly Accelerated Fibrosarcoma Kinase Alteration Positive