Autologous UV-oHSV2-activated Peripheral Blood Mononuclear Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous peripheral blood mononuclear cells (PBMCs) activated ex vivo by ultraviolet-inactivated oncolytic herpes simplex virus type 2 (UV-oHSV2), with potential immunomodulating and antineoplastic activities. Upon reintroduction of the autologous UV-oHSV2-activated PBMCs into the patient, the activated immune cells kill tumor cells. Ex vivo UV-oHSV2 treatment induces natural killer (NK) cell proliferation and the secretion of interferon-gamma (IFNg). This leads to immune-mediated tumor cell death and the inhibition of tumor cell proliferation.

**Synonyms:** - Autologous UV-oHSV2-activated PBMCs - Autologous Ultraviolet Inactivated Oncolytic Herpes Simplex Virus Type 2-activated Peripheral Blood Mononuclear Cells - Autologous VAK Immune Cells - Autologous Virus-activated Killer Immune Cells