Hereditary Tumor Syndrome Associated with Homologous Recombination Pathway Mutations

**Semantic type:** Disease or Syndrome

**Definition:** A hereditary neoplastic syndrome characterized by germline mutations of homologous recombination (HR) pathway genes. It is associated with an increased risk of developing various malignancies including breast, ovarian, pancreatic, and prostate carcinoma, and melanoma.

**Synonyms:** - Hereditary Homologous Recombination Cancer Syndrome