Fluorine F 18 GEH121224

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of a human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2)-targeting ligand labeled with the radioisotope fluorine F 18, with potential use as a tracer for HER2-expressing tumors during positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 GEH121224, the HER2-targeting moiety targets and binds to HER2-expressing tumor cells. Upon binding, HER2-expressing tumor cells can be detected during PET/CT imaging. HER2, a tumor-associated antigen (TAA) overexpressed on a variety of tumor cell types, plays an important role in tumor cell proliferation, differentiation and survival.

**Synonyms:** - 18F-GEH121224 - Fluorine F 18-labeled GEH121224 - GEH121224 (18F) - [18F]-GEH121224 - [18F]GEH121224