Autologous HPV16/HPV18/Survivin-specific CD8+ T-cells NEXI-003

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous CD3+ CD4- CD8+ T-cells targeting multiple human papilloma virus (HPV) tumor-associated antigens, including HPV types 16 and 18 antigens and survivin, with potential immunomodulating and antineoplastic activities. Following leukapheresis and ex vivo priming and expansion, the autologous HPV16/HPV18/survivin-specific CD8+ T-cells NEXI-003 are re-introduced into the patient, where they target and kill tumor cells expressing these HPV tumor-associated antigens.

**Synonyms:** - Autologous HPV Tumor-relevant Antigen-specific CD8+ T-cells NEXI-003 - CD3+ CD4- CD8+ T-cells NEXI-003 - NEXI 003 - NEXI-003 - NEXI003