Autologous IL-7Ra-expressing Tris-CAR T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified and lentivirally transduced to express a dual-target chimeric antigen receptor (CAR) and a truncated form of the cytokine receptor interleukin-7 (IL-7) receptor alpha (IL-7Ra), with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-7Ra-expressing Tris-CAR T-cells target and bind to tumor cells expressing the targets, thereby inducing selective toxicity in these tumor cells. In addition, as IL-7/IL-7Ra-mediated signaling promotes the proliferation and survival of T-cells, these tumor re-directed T-cells may show enhanced expansion, survival and cytotoxicity.

**Synonyms:** - Autologous Inverse-correlated Dual-target Truncated IL7Ra-modified CAR-expressing T-lymphocytes - Autologous Tris-CAR-T Cells