JNK1 Inhibitor BMS-986360

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, second-generation inhibitor of c-Jun N-terminal kinase 1 (JNK-1; JNK1; mitogen-activated protein kinase 8; MAPK8), with potential antineoplastic, anti-inflammatory and anti-fibrotic activities. Upon oral administration, JNK1 inhibitor BMS-986360 selectively targets, binds to and inhibits the activity of JNK1. Inhibition of JNK1-mediated mitogen-activated protein kinase (MAPK)-signaling pathways induces cell cycle arrest and apoptosis, decreases migration and invasion, and inhibits proliferation in JNK1-overexpressing cancer cells. Inhibition of JNK1-mediated pathways may also decrease fibrosis. JNK1, a member of the MAPK family and stress-activated protein, plays a role in the MAPK-mediated signaling pathway. It is often dysregulated in cancer cells and fibrosis.

**Synonyms:** - BMS 986360 - BMS-986360 - BMS986360 - CC 90001 - CC-90001 - CC-90001 - CC90001 - JNK1 Inhibitor CC-90001 - Mitogen-Activated Protein Kinase 8 Inhibitor BMS-986360 - c-Jun N-terminal Kinase Inhibitor BMS-986360