3-Deazauridine

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position. 3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells.(NCI04)

**Synonyms:** - 2(1H)-pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl - 3-DEAZAURIDINE - 4-hydroxy-1-(beta-D-ribopentofuranosyl)-2-pyridone - Deazauridine