Glutamate Decarboxylase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** A lyase that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2), which uses pyridoxal-phosphate (PLP) as a cofactor. There are two human isoforms of glutamate decarboxylase that are responsible for maintaining the majority of the physiological supply of GABA.

**Synonyms:** - EC 4.1.1.15 - GAD - GAD - GLUTAMIC ACID DECARBOXYLASE - Glutamic Acid Decarboxylase