Gallium Ga 68 N188

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of a nectin-4 (poliovirus receptor-like 4; PVRL4)-targeting moiety, labeled with gallium Ga 68, with potential nectin-4 imaging activity during positron emission topography (PET)/computed tomography (CT). After intravenous administration of gallium Ga 68 N188, the nectin-4-targeting moiety selectively targets and binds to nectin-4 expressed on tumor cells. Upon PET/CT imaging, nectin-4-expressing tumor cells can be visualized. Nectin-4, a tumor-associated antigen (TAA) belonging to the nectin family, is overexpressed in a variety of cancers, but has a restricted distribution in normal tissue.

**Synonyms:** - 68Ga-N188 - Gallium Ga 68-N188 - [68Ga]N188