Aldehyde Dehydrogenase 3 Family

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** A subfamily of the aldehyde dehydrogenase enzyme family that plays a role in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. Aberrant expression of these enzymes has been characterized in many cancer cell types and in cancer stem cells, where they may promote both cell survival and treatment resistance.

**Synonyms:** - ALDH3 - ALDH3 Family - Aldehyde Dehydrogenase 3