Anti-ROR1/Anti-CD3 Bispecific Antibody EMB-07

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific antibody directed against both the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/anti-CD3 bispecific antibody EMB-07 binds to both ROR1 expressed on tumor cells and CD3 expressed on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival.

**Synonyms:** - Anti-ROR1/CD3 Bispecific Antibody EMB-07 - EMB 07 - EMB-07 - EMB07 - ROR1 x CD3 Bispecific Antibody EMB-07