Marchiafava-Bignami Disease

**Semantic type:** Disease or Syndrome

**Definition:** A rare neurological disorder characterized initially by selective demyelination and necrosis of the corpus callosum. It is associated with chronic ethanol consumption or malnutrition, and depending on the acuity of presentation, signs and symptoms may include an altered mental state, motor disturbances, seizures, delirium and coma.

**Synonyms:** - Central Demyelination of Corpus Callosum - Central demyelination of corpus callosum