Lymphocytic Variant Hypereosinophilic Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A hypereosinophilic syndrome characterized by the presence of a clonal T-cell population. Patients present with cutaneous findings including eczematous dermatitis, nodules, papules, and pruritis, rheumatological symptoms, gastrointestinal symptoms, and lymphadenopathy. Lymph node biopsies show eosinophilia, atypical lymphocytes, clonally rearranged T-cells, and architectural distortion. Skin biopsies may also show the clonally rearranged T-cell population.

**Synonyms:** - LHES - LHS - Lymphocytic Variant Hypereosinophilic Syndrome [LHES]